MYCN protein stability is a better prognostic indicator in neuroblastoma

MYCN protein stability is a better prognostic indicator in neuroblastoma

Highlights The MYCN gene test is most valuable for INSS stage 3 patients to predict prognosis. Compared to gene status, MYCN protein expression is more relevant to prognosis. Combining FISH with IHC, MYCN protein stability could be identified.

Bibliographic Details
Main Authors: Yi Yang, Jie Zhao, Yingwen Zhang, Tianyue Feng, Bo Yv, Jing Wang, Yijin Gao, Minzhi Yin, Jingyan Tang, Yanxin Li
Format: Article
Language:English
Published: BMC 2022-07-01
Series:BMC Pediatrics
Subjects:
Neuroblastoma
MYCN
IHC
FISH
Protein stability
Online Access:https://doi.org/10.1186/s12887-022-03449-1

Internet

https://doi.org/10.1186/s12887-022-03449-1

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