MYCN protein stability is a better prognostic indicator in neuroblastoma
Highlights The MYCN gene test is most valuable for INSS stage 3 patients to predict prognosis. Compared to gene status, MYCN protein expression is more relevant to prognosis. Combining FISH with IHC, MYCN protein stability could be identified.
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-07-01
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| Series: | BMC Pediatrics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12887-022-03449-1 |
| _version_ | 1818510530638249984 |
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| author | Yi Yang Jie Zhao Yingwen Zhang Tianyue Feng Bo Yv Jing Wang Yijin Gao Minzhi Yin Jingyan Tang Yanxin Li |
| author_facet | Yi Yang Jie Zhao Yingwen Zhang Tianyue Feng Bo Yv Jing Wang Yijin Gao Minzhi Yin Jingyan Tang Yanxin Li |
| author_sort | Yi Yang |
| collection | DOAJ |
| description | Highlights The MYCN gene test is most valuable for INSS stage 3 patients to predict prognosis. Compared to gene status, MYCN protein expression is more relevant to prognosis. Combining FISH with IHC, MYCN protein stability could be identified. |
| first_indexed | 2024-12-10T23:21:14Z |
| format | Article |
| id | doaj.art-b9a516be62bb4b289619018cae54bf72 |
| institution | Directory Open Access Journal |
| issn | 1471-2431 |
| language | English |
| last_indexed | 2024-12-10T23:21:14Z |
| publishDate | 2022-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pediatrics |
| spelling | doaj.art-b9a516be62bb4b289619018cae54bf722022-12-22T01:29:43ZengBMCBMC Pediatrics1471-24312022-07-0122111110.1186/s12887-022-03449-1MYCN protein stability is a better prognostic indicator in neuroblastomaYi Yang0Jie Zhao1Yingwen Zhang2Tianyue Feng3Bo Yv4Jing Wang5Yijin Gao6Minzhi Yin7Jingyan Tang8Yanxin Li9Pediatric Translational Medicine Institute, Department of Hematology & Oncology, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, National Health Committee Key Laboratory of Pediatric Hematology & OncologyDepartment of Hematology & Oncology, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, National Health Committee Key Laboratory of Pediatric Hematology & OncologyPediatric Translational Medicine Institute, Department of Hematology & Oncology, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, National Health Committee Key Laboratory of Pediatric Hematology & OncologyPediatric Translational Medicine Institute, Department of Hematology & Oncology, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, National Health Committee Key Laboratory of Pediatric Hematology & OncologyState Key Laboratory of Oncogenes and Related Genes, Renji-Med X Clinical Stem Cell Research Center, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong UniversityDepartment of general Surgery/Surgical Oncology Center, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of MedicineDepartment of Hematology & Oncology, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, National Health Committee Key Laboratory of Pediatric Hematology & OncologyDepartment of Pathology, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of MedicineDepartment of Hematology & Oncology, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, National Health Committee Key Laboratory of Pediatric Hematology & OncologyPediatric Translational Medicine Institute, Department of Hematology & Oncology, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, National Health Committee Key Laboratory of Pediatric Hematology & OncologyHighlights The MYCN gene test is most valuable for INSS stage 3 patients to predict prognosis. Compared to gene status, MYCN protein expression is more relevant to prognosis. Combining FISH with IHC, MYCN protein stability could be identified.https://doi.org/10.1186/s12887-022-03449-1NeuroblastomaMYCNIHCFISHProtein stability |
| spellingShingle | Yi Yang Jie Zhao Yingwen Zhang Tianyue Feng Bo Yv Jing Wang Yijin Gao Minzhi Yin Jingyan Tang Yanxin Li MYCN protein stability is a better prognostic indicator in neuroblastoma BMC Pediatrics Neuroblastoma MYCN IHC FISH Protein stability |
| title | MYCN protein stability is a better prognostic indicator in neuroblastoma |
| title_full | MYCN protein stability is a better prognostic indicator in neuroblastoma |
| title_fullStr | MYCN protein stability is a better prognostic indicator in neuroblastoma |
| title_full_unstemmed | MYCN protein stability is a better prognostic indicator in neuroblastoma |
| title_short | MYCN protein stability is a better prognostic indicator in neuroblastoma |
| title_sort | mycn protein stability is a better prognostic indicator in neuroblastoma |
| topic | Neuroblastoma MYCN IHC FISH Protein stability |
| url | https://doi.org/10.1186/s12887-022-03449-1 |
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