Anosmin-1-Like Effect of UMODL1/Olfactorin on the Chemomigration of Mouse GnRH Neurons and Zebrafish Olfactory Axons Development

Anosmin-1-Like Effect of UMODL1/Olfactorin on the Chemomigration of Mouse GnRH Neurons and Zebrafish Olfactory Axons Development

The impairment of development/migration of hypothalamic gonadotropin-releasing hormone (GnRH) neurons is the main cause of Kallmann's syndrome (KS), an inherited disorder characterized by hypogonadism, anosmia, and other developmental defects. Olfactorin is an extracellular matrix protein encod...

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Bibliographic Details
Main Authors: Elia Di Schiavi, Giulio Vistoli, Roberta Manuela Moretti, Ilaria Corrado, Giulia Zuccarini, Silvia Gervasoni, Lavinia Casati, Daniele Bottai, Giorgio Roberto Merlo, Roberto Maggi
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
GnRH (gonadotropin-releasing hormone)
anosmin-1
olfactorin
UMODL1
hypothalamus and neuroendocrinology
olfactory axons
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.836179/full

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https://www.frontiersin.org/articles/10.3389/fcell.2022.836179/full

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