Validation and Optimization of an Ex Vivo Assay of Intestinal Mucosal Biopsies in Crohn's Disease: Reflects Inflammation and Drug Effects.

Validation and Optimization of an Ex Vivo Assay of Intestinal Mucosal Biopsies in Crohn's Disease: Reflects Inflammation and Drug Effects.

Crohn's disease (CD) is a chronic illness demanding better therapeutics. The marketed biologics only benefit some patients or elicit diminishing effect over time. To complement the known methods in drug development and to obtain patient specific drug responses, we optimized and validated a know...

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Main Authors: Kasper Vadstrup, Elisabeth Douglas Galsgaard, Jens Gerwien, Marianne Kajbæk Vester-Andersen, Julie Steen Pedersen, Julie Rasmussen, Søren Neermark, Marianne Kiszka-Kanowitz, Teis Jensen, Flemming Bendtsen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4865152?pdf=render

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http://europepmc.org/articles/PMC4865152?pdf=render

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