High-performance lung-targeted bio-responsive platform for severe colistin-resistant bacterial pneumonia therapy

High-performance lung-targeted bio-responsive platform for severe colistin-resistant bacterial pneumonia therapy

Polymyxins are the last line of defense against multidrug-resistant (MDR) Gram-negative bacterial infections. However, this last resort has been threatened by the emergence of superbugs carrying the mobile colistin resistance gene-1 (mcr-1). Given the high concentration of matrix metalloproteinase 3...

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Bibliographic Details
Main Authors: Decui Cheng, Rui Tian, Tingting Pan, Qiang Yu, Li Wei, Jiaozhi Liyin, Yunqi Dai, Xiaoli Wang, Ruoming Tan, Hongping Qu, Min Lu
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2024-05-01
Series:Bioactive Materials
Subjects:
Colistin-resistant bacteria
MCR-1
Lung targeting
Matrix metalloproteinase 3
Synergistic action
Bacterial severe pneumonia
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X24000628

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http://www.sciencedirect.com/science/article/pii/S2452199X24000628

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