Liver knockout of MCU leads to greater dysregulation of lipid metabolism in MAFLD

Liver knockout of MCU leads to greater dysregulation of lipid metabolism in MAFLD

Abstract Metabolic-associated fatty liver disease (MAFLD) is a common chronic condition that poses a significant threat to human health. Mitochondrial dysfunction, particularly involving the mitochondrial Ca2+ uniporter (MCU), plays a key role in its pathogenesis. This study aimed to investigate the...

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Bibliographic Details
Main Authors: Qichao Liao, Yurou Zhang, Tingli Pan, Yu Sun, Siqi Liu, Zhiwang Zhang, Yixing Li, Lin Yu, Zupeng Luo, Yang Xiao, Xinyi Qi, Tianyu Jiang, Songtao Su, Shi Liu, Xinyu Qi, Xiangling Li, Turtushikh Damba, Khongorzul Batchuluun, Yunxiao Liang, Suosu Wei, Lei Zhou
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
MCU
MAFLD
Fat liver
Lipid transport-associated
Lipid dysregulation
Online Access:https://doi.org/10.1038/s41598-024-78935-w

Internet

https://doi.org/10.1038/s41598-024-78935-w

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