Liver knockout of MCU leads to greater dysregulation of lipid metabolism in MAFLD

Liver knockout of MCU leads to greater dysregulation of lipid metabolism in MAFLD

Abstract Metabolic-associated fatty liver disease (MAFLD) is a common chronic condition that poses a significant threat to human health. Mitochondrial dysfunction, particularly involving the mitochondrial Ca2+ uniporter (MCU), plays a key role in its pathogenesis. This study aimed to investigate the...

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Podrobná bibliografie
Hlavní autoři: Qichao Liao, Yurou Zhang, Tingli Pan, Yu Sun, Siqi Liu, Zhiwang Zhang, Yixing Li, Lin Yu, Zupeng Luo, Yang Xiao, Xinyi Qi, Tianyu Jiang, Songtao Su, Shi Liu, Xinyu Qi, Xiangling Li, Turtushikh Damba, Khongorzul Batchuluun, Yunxiao Liang, Suosu Wei, Lei Zhou
Médium: Článek
Jazyk:English
Vydáno: Nature Portfolio 2024-11-01
Edice:Scientific Reports
Témata:
MCU
MAFLD
Fat liver
Lipid transport-associated
Lipid dysregulation
On-line přístup:https://doi.org/10.1038/s41598-024-78935-w

Internet

https://doi.org/10.1038/s41598-024-78935-w

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