Construction of VSVΔ51M oncolytic virus expressing human interleukin-12

Construction of VSVΔ51M oncolytic virus expressing human interleukin-12

The use of oncolytic viruses (OVs) in combination with cytokines, such as IL-12, is a promising approach for cancer treatment that addresses the limitations of current standard treatments and traditional cancer immunotherapies. IL-12, a proinflammatory cytokine, triggers intracellular signaling path...

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Bibliographic Details
Main Authors: Rwaa H. Abdulal, Jana S. Malki, Ezdehar Ghazal, Ahdab A. Alsaieedi, Sarah A. Almahboub, Muhammad Yasir Khan, Reem M. Alsulaiman, Mazen M. Ghaith, Turki S. Abujamel, Magdah Ganash, Ahmad Bakur Mahmoud, Almohanad A. Alkayyal, Anwar M. Hashem
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Molecular Biosciences
Subjects:
oncolytic virus
VSVΔ51M
interleukin-12
cancer immunotherapy
B16F10
MCF-7
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2023.1190669/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2023.1190669/full

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