Characterisation of macrophage infiltration and polarisation based on integrated transcriptomic and histological analyses in Primary Sjögren’s syndrome

Characterisation of macrophage infiltration and polarisation based on integrated transcriptomic and histological analyses in Primary Sjögren’s syndrome

BackgroundPrimary Sjögren’s syndrome (pSS) is a progressive inflammatory autoimmune disease. Immune cell infiltration into glandular lobules and ducts and glandular destruction are the pathophysiological hallmarks of pSS. Macrophages are one of the most important cells involved in the induction and...

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Bibliographic Details
Main Authors: Yuan Zong, Yi Yang, Jiawen Zhao, Lei Li, Danyang Luo, Jiawei Hu, Yiming Gao, Li Wei, Ning Li, Liting Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Immunology
Subjects:
Sjogren’ s syndrome
immune microenvironment
macrophage
senescence-associated secreted phenotype (SASP)
single-cell RNA analysis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1292146/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1292146/full

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