Identifying targetable metabolic dependencies across colorectal cancer progression

Identifying targetable metabolic dependencies across colorectal cancer progression

Colorectal cancer (CRC) is a multi-stage process initiated through the formation of a benign adenoma, progressing to an invasive carcinoma and finally metastatic spread. Tumour cells must adapt their metabolism to support the energetic and biosynthetic demands associated with disease progression. As...

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Bibliographic Details
Main Authors: Danny N. Legge, Tracey J. Collard, Ewelina Stanko, Ashley J. Hoskin, Amy K. Holt, Caroline J. Bull, Madhu Kollareddy, Jake Bellamy, Sarah Groves, Eric H. Ma, Emma Hazelwood, David Qualtrough, Borko Amulic, Karim Malik, Ann C. Williams, Nicholas Jones, Emma E. Vincent
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Molecular Metabolism
Subjects:
Colorectal cancer
Oncometabolism
Asparagine
Asparagine synthetase
Adenoma
Adenocarcinoma
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877824001686

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http://www.sciencedirect.com/science/article/pii/S2212877824001686

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