DNA damage-mediated cellular senescence promotes hand-foot syndrome that can be relieved by thymidine prodrug

DNA damage-mediated cellular senescence promotes hand-foot syndrome that can be relieved by thymidine prodrug

Hand-foot syndrome (HFS) is a widely recognized dose-limiting cutaneous toxicity effect of fluoropyrimidine chemotherapy agents that impairs clinical benefits and treatment outcomes. Even though the cause and pathophysiology of HFS are relatively widely reported, how the toxicity of fluoropyrimidine...

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Bibliographic Details
Main Authors: Bingxue Yang, Xinran Xie, Zhaoyu Wu, Dazhao Lv, Jiajun Hu, Yuyun Chen, Jiaxing Li, Shuyue Luo, Jiacheng Li, Jie Luo, Shiyi Zhang
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2023-11-01
Series:Genes and Diseases
Subjects:
Cellular senescence
cGAS-STING
Cutaneous toxicity
DNA damage
Fluoropyrimidine
Hand-foot syndrome
Online Access:http://www.sciencedirect.com/science/article/pii/S2352304222002677

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http://www.sciencedirect.com/science/article/pii/S2352304222002677

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