Per- and polyfluoroalkyl substances inhibit human and rat 17β-hydroxysteroid dehydrogenase 1: Quantitative structure-activity relationship and molecular docking analysis

Per- and polyfluoroalkyl substances inhibit human and rat 17β-hydroxysteroid dehydrogenase 1: Quantitative structure-activity relationship and molecular docking analysis

Per- and polyfluoroalkyl (PFAS) substances are enduring industrial materials. 17β-Hydroxysteroid dehydrogenase isoform 1 (17β-HSD1) is an estrogen metabolizing enzyme, which transforms estrone into estradiol in human placenta and rat ovary. Whether PFAS inhibit 17β-HSD1 and what the structure-activi...

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Bibliographic Details
Main Authors: Chao Wen, Huan Chen, Yunbing Tang, Hang Lin, Congcong Xu, Yingfen Ying, Yang Zhu, Xinjun Miao, Ren-shan Ge, Chao Chen, Shangqin Chen
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Ecotoxicology and Environmental Safety
Subjects:
17β-HSD1
PFAS
Steroidogenesis
Docking analysis
3D-QSAR
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651324002483

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http://www.sciencedirect.com/science/article/pii/S0147651324002483

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