Diffuse microglial responses and persistent EEG changes correlate with poor neurological outcome in a model of subarachnoid hemorrhage

Diffuse microglial responses and persistent EEG changes correlate with poor neurological outcome in a model of subarachnoid hemorrhage

Abstract The mechanism by which subarachnoid hemorrhage (SAH) leads to chronic neurologic deficits is unclear. One possibility is that blood activates microglia to drive inflammation that leads to synaptic loss and impaired brain function. Using the endovascular perforation model of SAH in rats, we...

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Bibliographic Details
Main Authors: Joseph R. Geraghty, Mitchell Butler, Biswajit Maharathi, Alexander J. Tate, Tyler J. Lung, Giri Balasubramanian, Fernando D. Testai, Jeffrey A. Loeb
Format: Article
Language:English
Published: Nature Portfolio 2024-06-01
Series:Scientific Reports
Subjects:
Subarachnoid hemorrhage
Electroencephalography
Spectral analysis
Inflammation
Microglia
Fingolimod
Online Access:https://doi.org/10.1038/s41598-024-64631-2

Internet

https://doi.org/10.1038/s41598-024-64631-2

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