PGC-1α repression dysregulates lipid metabolism and induces lipid droplet accumulation in the retinal pigment epithelium

PGC-1α repression dysregulates lipid metabolism and induces lipid droplet accumulation in the retinal pigment epithelium

Abstract Drusen, the yellow deposits under the retina, are composed of lipids and proteins, and represent a hallmark of age-related macular degeneration (AMD). Lipid droplets are also reported in the retinal pigment epithelium (RPE) from AMD donor eyes. However, the mechanisms underlying these disea...

Full description

Bibliographic Details
Main Authors: Shuyan Zhou, Kaan Taskintuna, Jacob Hum, Jasmine Gulati, Stephanie Olaya, Jeremy Steinman, Nady Golestaneh
Format: Article
Language:English
Published: Nature Publishing Group 2024-06-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-024-06762-y

Internet

https://doi.org/10.1038/s41419-024-06762-y

Similar Items