Melatonin Enhances the Therapeutic Effect of Plasma Exosomes Against Cerebral Ischemia-Induced Pyroptosis Through the TLR4/NF-κB Pathway

Melatonin Enhances the Therapeutic Effect of Plasma Exosomes Against Cerebral Ischemia-Induced Pyroptosis Through the TLR4/NF-κB Pathway

IntroductionIschemic stroke-induced inflammation and inflammasome-dependent pyroptotic neural death cause serious neurological injury. Nano-sized plasma exosomes have exhibited therapeutic potential against ischemia and reperfusion injury by ameliorating inflammation. To enhance its therapeutic pote...

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Bibliographic Details
Main Authors: Kankai Wang, Junnan Ru, Hengli Zhang, Jiayu Chen, Xiao Lin, Zhongxiao Lin, Min Wen, Lijie Huang, Haoqi Ni, Qichuan Zhuge, Su Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Neuroscience
Subjects:
ischemic stroke
melatonin
plasma exosome
pyroptosis
inflammatory response
TLR4/NF-κB signaling pathway
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2020.00848/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2020.00848/full

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