Real-time imaging of Huntingtin aggregates diverting target search and gene transcription

Real-time imaging of Huntingtin aggregates diverting target search and gene transcription

The presumptive altered dynamics of transient molecular interactions in vivo contributing to neurodegenerative diseases have remained elusive. Here, using single-molecule localization microscopy, we show that disease-inducing Huntingtin (mHtt) protein fragments display three distinct dynamic states...

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Bibliographic Details
Main Authors: Li Li, Hui Liu, Peng Dong, Dong Li, Wesley R Legant, Jonathan B Grimm, Luke D Lavis, Eric Betzig, Robert Tjian, Zhe Liu
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-08-01
Series:eLife
Subjects:
huntingtin aggregates
transcription factors
chromatin
Online Access:https://elifesciences.org/articles/17056

Internet

https://elifesciences.org/articles/17056

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