Initial clinical validation of a hybrid in silico—in vitro cardiorespiratory simulator for comprehensive testing of mechanical circulatory support systems

Simulators are expected to assume a prominent role in the process of design—development and testing of cardiovascular medical devices. For this purpose, simulators should capture the complexity of human cardiorespiratory physiology in a realistic way. High fidelity simulations of pathophysiology do...

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Bibliographic Details
Main Authors: Libera Fresiello, Kavitha Muthiah, Kaatje Goetschalckx, Christopher Hayward, Maria Rocchi, Maxime Bezy, Jo P. Pauls, Bart Meyns, Dirk W. Donker, Krzysztof Zieliński
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Physiology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2022.967449/full