Mouse brain contains age-dependent extraparenchymal granular structures and astrocytes, both reactive to natural IgM antibodies, linked to the fissura magna

Mouse brain contains age-dependent extraparenchymal granular structures and astrocytes, both reactive to natural IgM antibodies, linked to the fissura magna

Abstract Background Mouse brains can contain specific polyglucosan aggregates known as Periodic Acid-Schiff (PAS)-granules. Generated in astrocytes, these granules increase with age and exhibit neo-epitopes of carbohydrate nature that are recognized by natural IgM antibodies (IgMs). The existence of...

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Bibliographic Details
Main Authors: Clara Romera, Marta Riba, Raquel Alsina, Marina Sartorio, Jordi Vilaplana, Carme Pelegrí, Jaume del Valle
Format: Article
Language:English
Published: BMC 2024-08-01
Series:Immunity & Ageing
Subjects:
Ageing
Brain
Immune surveillance
Natural antibodies
Neo-epitopes
EP granules
Online Access:https://doi.org/10.1186/s12979-024-00460-1

Internet

https://doi.org/10.1186/s12979-024-00460-1

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