Dynamic Preference for NADP/H Cofactor Binding/Release in <i>E. coli</i> YqhD Oxidoreductase

Dynamic Preference for NADP/H Cofactor Binding/Release in <i>E. coli</i> YqhD Oxidoreductase

YqhD, an <i>E. coli</i> alcohol/aldehyde oxidoreductase, is an enzyme able to produce valuable bio-renewable fuels and fine chemicals from a broad range of starting materials. Herein, we report the first computational solution-phase structure-dynamics analysis of YqhD, shedding light on...

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Bibliographic Details
Main Authors: Rajni Verma, Jonathan M. Ellis, Katie R. Mitchell-Koch
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Molecules
Subjects:
NAD(P)H-dependent oxidoreductase
zinc-containing alcohol dehydrogenase
cofactor binding and release
interdomain cleft dynamics
molecular dynamics simulations
Online Access:https://www.mdpi.com/1420-3049/26/2/270

Internet

https://www.mdpi.com/1420-3049/26/2/270

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