Metformin regulates lipid metabolism in a canine model of atrial fibrillation through AMPK/PPAR-α/VLCAD pathway

Metformin regulates lipid metabolism in a canine model of atrial fibrillation through AMPK/PPAR-α/VLCAD pathway

Abstract Background Atrial lipid metabolic remodeling is critical for the process of atrial fibrillation (AF). Abnormal Fatty acid (FA) metabolism in cardiomyocytes is involved in the pathogenesis of AF. MET (Metformin), an AMPK (AMP-activated protein kinase) activator, has been found to be associat...

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Bibliographic Details
Main Authors: Fan Bai, Yaozhong Liu, Tao Tu, Biao Li, Yichao Xiao, Yingxu Ma, Fen Qin, Jing Xie, Shenghua Zhou, Qiming Liu
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Lipids in Health and Disease
Subjects:
Atrial fibrillation
Lipid metabolism
AMPK
Metformin
Online Access:http://link.springer.com/article/10.1186/s12944-019-1059-7

Internet

http://link.springer.com/article/10.1186/s12944-019-1059-7

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