Microbial transformation of lovastatin by Beauveria bassiana

Microbial transformation of lovastatin by Beauveria bassiana

Microbial transformation of lovastatin (1) by resting cells of a filamentous fungus, Beauveria bassiana AS 3.4270, yielded five metabolites (2–6), which were unambiguously characterized by various spectroscopic data analyses. The occurred reactions included hydroxylation, lactone hydrolysis and meth...

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Bibliographic Details
Main Authors: Lirui Qiao, Dan Xie, Quan Liu, Jianhua Zou, Zhufang Shen, Jungui Dai
Format: Article
Language:English
Published: Elsevier 2012-06-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Lovastatin
Microbial transformation
Beauveria bassiana AS 3.4270
Resting cells
HMG-CoA reductase
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383512000640

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http://www.sciencedirect.com/science/article/pii/S2211383512000640

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