Microbial transformation of lovastatin by Beauveria bassiana
Microbial transformation of lovastatin (1) by resting cells of a filamentous fungus, Beauveria bassiana AS 3.4270, yielded five metabolites (2–6), which were unambiguously characterized by various spectroscopic data analyses. The occurred reactions included hydroxylation, lactone hydrolysis and meth...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2012-06-01
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| Series: | Acta Pharmaceutica Sinica B |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211383512000640 |
| _version_ | 1818120275334529024 |
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| author | Lirui Qiao Dan Xie Quan Liu Jianhua Zou Zhufang Shen Jungui Dai |
| author_facet | Lirui Qiao Dan Xie Quan Liu Jianhua Zou Zhufang Shen Jungui Dai |
| author_sort | Lirui Qiao |
| collection | DOAJ |
| description | Microbial transformation of lovastatin (1) by resting cells of a filamentous fungus, Beauveria bassiana AS 3.4270, yielded five metabolites (2–6), which were unambiguously characterized by various spectroscopic data analyses. The occurred reactions included hydroxylation, lactone hydrolysis and methylation. The inhibitory effects of all metabolites on the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase were evaluated. Of the five compounds, 4 exhibited comparable inhibitory effect to lovastatin on the HMG-CoA reductase with IC50 value of 2.2 μM, and inhibitory rate of 81.4%. |
| first_indexed | 2024-12-11T05:23:30Z |
| format | Article |
| id | doaj.art-b9d81cb31274485c92b3fbca41302787 |
| institution | Directory Open Access Journal |
| issn | 2211-3835 2211-3843 |
| language | English |
| last_indexed | 2024-12-11T05:23:30Z |
| publishDate | 2012-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Acta Pharmaceutica Sinica B |
| spelling | doaj.art-b9d81cb31274485c92b3fbca413027872022-12-22T01:19:38ZengElsevierActa Pharmaceutica Sinica B2211-38352211-38432012-06-012330030510.1016/j.apsb.2012.04.001Microbial transformation of lovastatin by Beauveria bassianaLirui QiaoDan XieQuan LiuJianhua ZouZhufang ShenJungui DaiMicrobial transformation of lovastatin (1) by resting cells of a filamentous fungus, Beauveria bassiana AS 3.4270, yielded five metabolites (2–6), which were unambiguously characterized by various spectroscopic data analyses. The occurred reactions included hydroxylation, lactone hydrolysis and methylation. The inhibitory effects of all metabolites on the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase were evaluated. Of the five compounds, 4 exhibited comparable inhibitory effect to lovastatin on the HMG-CoA reductase with IC50 value of 2.2 μM, and inhibitory rate of 81.4%.http://www.sciencedirect.com/science/article/pii/S2211383512000640LovastatinMicrobial transformationBeauveria bassiana AS 3.4270Resting cellsHMG-CoA reductase |
| spellingShingle | Lirui Qiao Dan Xie Quan Liu Jianhua Zou Zhufang Shen Jungui Dai Microbial transformation of lovastatin by Beauveria bassiana Acta Pharmaceutica Sinica B Lovastatin Microbial transformation Beauveria bassiana AS 3.4270 Resting cells HMG-CoA reductase |
| title | Microbial transformation of lovastatin by Beauveria bassiana |
| title_full | Microbial transformation of lovastatin by Beauveria bassiana |
| title_fullStr | Microbial transformation of lovastatin by Beauveria bassiana |
| title_full_unstemmed | Microbial transformation of lovastatin by Beauveria bassiana |
| title_short | Microbial transformation of lovastatin by Beauveria bassiana |
| title_sort | microbial transformation of lovastatin by beauveria bassiana |
| topic | Lovastatin Microbial transformation Beauveria bassiana AS 3.4270 Resting cells HMG-CoA reductase |
| url | http://www.sciencedirect.com/science/article/pii/S2211383512000640 |
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