The mitochondrial pyruvate carrier mediates high fat diet-induced increases in hepatic TCA cycle capacity

The mitochondrial pyruvate carrier mediates high fat diet-induced increases in hepatic TCA cycle capacity

Objective: Excessive hepatic gluconeogenesis is a defining feature of type 2 diabetes (T2D). Most gluconeogenic flux is routed through mitochondria. The mitochondrial pyruvate carrier (MPC) transports pyruvate from the cytosol into the mitochondrial matrix, thereby gating pyruvate-driven gluconeogen...

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Bibliographic Details
Main Authors: Adam J. Rauckhorst, Lawrence R. Gray, Ryan D. Sheldon, Xiaorong Fu, Alvin D. Pewa, Charlotte R. Feddersen, Adam J. Dupuy, Katherine N. Gibson-Corley, James E. Cox, Shawn C. Burgess, Eric B. Taylor
Format: Article
Language:English
Published: Elsevier 2017-11-01
Series:Molecular Metabolism
Subjects:
Mitochondrial pyruvate carrier (MPC)
Liver
Diabetes
Gluconeogenesis
Fibrosis
Inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877817306828

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http://www.sciencedirect.com/science/article/pii/S2212877817306828

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