Activin A Causes Muscle Atrophy through MEF2C-Dependent Impaired Myogenesis

Activin A Causes Muscle Atrophy through MEF2C-Dependent Impaired Myogenesis

Activin A (ActA) is considered to play a major role in cancer-induced cachexia (CC). Indeed, circulating ActA levels are elevated and predict survival in patients with CC. However, the mechanisms by which ActA mediates CC development and in particular skeletal muscle (SM) atrophy in humans are not y...

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Bibliographic Details
Main Authors: Audrey Loumaye, Pascale Lause, Xiaoling Zhong, Teresa A. Zimmers, Laure B. Bindels, Jean-Paul Thissen
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Cells
Subjects:
activin A
skeletal muscle
muscle atrophy
myogenesis
MEF2C
Online Access:https://www.mdpi.com/2073-4409/11/7/1119

Internet

https://www.mdpi.com/2073-4409/11/7/1119

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