Structural Basis of a Novel Agonistic Anti-OX40 Antibody

Structural Basis of a Novel Agonistic Anti-OX40 Antibody

Agonistic antibodies targeting co-stimulating receptor OX40 on T cells are considered as important as (or complementary to) the immune checkpoint blockers in cancer treatment. However, none of these agonistic antibodies have reached the late stage of clinical development partially due to the lack of...

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Bibliographic Details
Main Authors: Jing Zhang, Xiaoyong Jiang, Han Gao, Fei Zhang, Xin Zhang, Aiwu Zhou, Ting Xu, Haiyan Cai
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Biomolecules
Subjects:
OX40 antibody
crystal structure
agonistic
epitope specificity
cross-linking
Online Access:https://www.mdpi.com/2218-273X/12/9/1209

Internet

https://www.mdpi.com/2218-273X/12/9/1209

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