Gentiana lutea attenuates hepatotoxicity induced by ketoconazole in rats by fortifying the cellular antioxidant defense system

Abstract Background Ketoconazole (KET) is a broad-spectrum antifungal drug that has been reported to induce hepatotoxicity in humans and animals. Methods The safe guarding response of Gentiana extract (GEN) against KET-induced hepatotoxicity was investigated in this study using male Wistar rats. GEN...

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Bibliographic Details
Main Authors: Alaaeldin Ahmed Hamza, Mona Gamel, Ali Abdalla, Youssef Abdalla, Amr Amin
Format: Article
Language:English
Published: SpringerOpen 2023-01-01
Series:Journal of Basic and Applied Zoology
Subjects:
Online Access:https://doi.org/10.1186/s41936-022-00321-7