Subsets of Tissue CD4 T Cells Display Different Susceptibilities to HIV Infection and Death: Analysis by CyTOF and Single Cell RNA-seq

Subsets of Tissue CD4 T Cells Display Different Susceptibilities to HIV Infection and Death: Analysis by CyTOF and Single Cell RNA-seq

CD4 T lymphocytes belong to diverse cellular subsets whose sensitivity or resistance to HIV-associated killing remains to be defined. Working with lymphoid cells from human tonsils, we characterized the HIV-associated depletion of various CD4 T cell subsets using mass cytometry and single-cell RNA-s...

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Bibliographic Details
Main Authors: Xiaoyu Luo, Julie Frouard, Gang Zhang, Jason Neidleman, Guorui Xie, Emma Sheedy, Nadia R. Roan, Warner C. Greene
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Immunology
Subjects:
human immunodeficiency virus (HIV)
cell death
apoptosis
pyroptosis
lymphoid tissues
mass cytometry
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.883420/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.883420/full

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