The 3-O sulfation of heparan sulfate proteoglycans contributes to the cellular internalization of tau aggregates

The 3-O sulfation of heparan sulfate proteoglycans contributes to the cellular internalization of tau aggregates

Abstract Background Considering the high correlation between the functional decline in Alzheimer’s disease (AD) and the propagation of aggregated tau protein, many research efforts are focused on determining the underlying molecular mechanisms of tau spreading. Heparan sulfate proteoglycans (HSPGs)...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Andreia Ferreira, Ines Royaux, Jian Liu, Zhangjie Wang, Guowei Su, Diederik Moechars, Nico Callewaert, Louis De Muynck
التنسيق: مقال
اللغة:English
منشور في: BMC 2022-12-01
سلاسل:BMC Molecular and Cell Biology
الموضوعات:
Tau uptake
Heparan sulfates proteoglycans
3-O sulfation
HS 3-O sulfotransferase 1
Tau-heparan sulfates interaction
الوصول للمادة أونلاين:https://doi.org/10.1186/s12860-022-00462-1

الانترنت

https://doi.org/10.1186/s12860-022-00462-1

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