The 3-O sulfation of heparan sulfate proteoglycans contributes to the cellular internalization of tau aggregates

The 3-O sulfation of heparan sulfate proteoglycans contributes to the cellular internalization of tau aggregates

Abstract Background Considering the high correlation between the functional decline in Alzheimer’s disease (AD) and the propagation of aggregated tau protein, many research efforts are focused on determining the underlying molecular mechanisms of tau spreading. Heparan sulfate proteoglycans (HSPGs)...

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Bibliographic Details
Main Authors: Andreia Ferreira, Ines Royaux, Jian Liu, Zhangjie Wang, Guowei Su, Diederik Moechars, Nico Callewaert, Louis De Muynck
Format: Article
Language:English
Published: BMC 2022-12-01
Series:BMC Molecular and Cell Biology
Subjects:
Tau uptake
Heparan sulfates proteoglycans
3-O sulfation
HS 3-O sulfotransferase 1
Tau-heparan sulfates interaction
Online Access:https://doi.org/10.1186/s12860-022-00462-1

Internet

https://doi.org/10.1186/s12860-022-00462-1

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