Inhibition of nitric oxide production of activated mice peritoneal macrophages is independent of the Toxoplasma gondii strain

Inhibition of nitric oxide production of activated mice peritoneal macrophages is independent of the Toxoplasma gondii strain

BACKGROUND Toxoplasma gondii causes toxoplasmosis and is controlled by activated macrophages. However, infection of macrophages by tachyzoites induces TGF-β signaling (TGF-s) inhibiting nitric oxide (NO) production. NO inhibition may be a general escape mechanism of distinct T. gondii strains. OBJE...

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Bibliographic Details
Main Authors: João Cláudio Damasceno-Sá, Fernanda Silva de Souza, Thiago Alves Teixeira dos Santos, Fábio Conceição de Oliveira, Maria de Fátima Sarro da Silva, Raul Ramos Furtado Dias, Wanderley de Souza, Andrea Cristina Veto Arnholdt, Sergio Henrique Seabra, Renato Augusto DaMatta
Format: Article
Language:English
Published: Fundação Oswaldo Cruz (FIOCRUZ) 2021-03-01
Series:Memorias do Instituto Oswaldo Cruz
Subjects:
activated macrophages
nitric oxide
inducible nitric oxide synthase
TGF-ꞵ signaling
LC3
virulence
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762021000100303&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762021000100303&tlng=en

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