Blockade of 11β-hydroxysteroid dehydrogenase type 1 ameliorates metabolic dysfunction-associated steatotic liver disease and fibrosis

Blockade of 11β-hydroxysteroid dehydrogenase type 1 ameliorates metabolic dysfunction-associated steatotic liver disease and fibrosis

11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) is a key enzyme involved in the conversion of cortisone to active cortisol in the liver. Elevated cortisol levels can trigger oxidative stress, inflammation, and hepatocyte damage, highlighting the importance of 11β-HSD1 inhibition as a potential th...

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Bibliographic Details
Main Authors: Hwan Ma, Guo-Yan Sui, Jeong-Su Park, Feng Wang, Yuanqiang Ma, Dong-Su Shin, Nodir Rustamov, Jun Sung Jang, Soo Im Chang, Jin Lee, Yoon Seok Roh
Format: Article
Language:English
Published: Elsevier 2024-10-01
Series:Heliyon
Subjects:
11β-HSD1
Cortisol
Cortisone
Lipid accumulation
Liver fibrosis
Online Access:http://www.sciencedirect.com/science/article/pii/S240584402415565X

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http://www.sciencedirect.com/science/article/pii/S240584402415565X

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