Ex vivo mass spectrometry-based biodistribution analysis of an antibody-Resiquimod conjugate bearing a protease-cleavable and acid-labile linker

Ex vivo mass spectrometry-based biodistribution analysis of an antibody-Resiquimod conjugate bearing a protease-cleavable and acid-labile linker

Immune-stimulating antibody conjugates (ISACs) equipped with imidazoquinoline (IMD) payloads can stimulate endogenous immune cells to kill cancer cells, ultimately inducing long-lasting anticancer effects. A novel ISAC was designed, featuring the IMD Resiquimod (R848), a tumor-targeting antibody spe...

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Bibliographic Details
Main Authors: Lydia Bisbal Lopez, Domenico Ravazza, Matilde Bocci, Aureliano Zana, Lucrezia Principi, Sheila Dakhel Plaza, Andrea Galbiati, Ettore Gilardoni, Jörg Scheuermann, Dario Neri, Luca Pignataro, Cesare Gennari, Samuele Cazzamalli, Alberto Dal Corso
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Pharmacology
Subjects:
immune stimulating antibody conjugates
Resiquimod
toll-like receptors
prodrugs
quantitative biodistribution
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1320524/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1320524/full

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