Lateral septum adenosine A2A receptors control stress-induced depressive-like behaviors via signaling to the hypothalamus and habenula
The mechanism underlying caffeine consumption inversely correlation with depression is unclear. Here, authors identified adenosine A2A receptor in the lateral septum mediating depressive symptoms via direct outputs to the habenula and the hypothalamus.
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-37601-x |
| _version_ | 1797849989277286400 |
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| author | Muran Wang Peijun Li Zewen Li Beatriz S. da Silva Wu Zheng Zhenghua Xiang Yan He Tao Xu Cristina Cordeiro Lu Deng Yuwei Dai Mengqian Ye Zhiqing Lin Jianhong Zhou Xuzhao Zhou Fenfen Ye Rodrigo A. Cunha Jiangfan Chen Wei Guo |
| author_facet | Muran Wang Peijun Li Zewen Li Beatriz S. da Silva Wu Zheng Zhenghua Xiang Yan He Tao Xu Cristina Cordeiro Lu Deng Yuwei Dai Mengqian Ye Zhiqing Lin Jianhong Zhou Xuzhao Zhou Fenfen Ye Rodrigo A. Cunha Jiangfan Chen Wei Guo |
| author_sort | Muran Wang |
| collection | DOAJ |
| description | The mechanism underlying caffeine consumption inversely correlation with depression is unclear. Here, authors identified adenosine A2A receptor in the lateral septum mediating depressive symptoms via direct outputs to the habenula and the hypothalamus. |
| first_indexed | 2024-04-09T18:53:05Z |
| format | Article |
| id | doaj.art-b9ef1ffd861e4ac290ccc3f70bc6e50e |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-09T18:53:05Z |
| publishDate | 2023-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-b9ef1ffd861e4ac290ccc3f70bc6e50e2023-04-09T11:20:39ZengNature PortfolioNature Communications2041-17232023-04-0114111710.1038/s41467-023-37601-xLateral septum adenosine A2A receptors control stress-induced depressive-like behaviors via signaling to the hypothalamus and habenulaMuran Wang0Peijun Li1Zewen Li2Beatriz S. da Silva3Wu Zheng4Zhenghua Xiang5Yan He6Tao Xu7Cristina Cordeiro8Lu Deng9Yuwei Dai10Mengqian Ye11Zhiqing Lin12Jianhong Zhou13Xuzhao Zhou14Fenfen Ye15Rodrigo A. Cunha16Jiangfan Chen17Wei Guo18The Molecular Neuropharmacology Laboratory and the Eye-Brain Research Center, The State Key Laboratory of Ophthalmology, Optometry and Vision Science, Wenzhou Medical UniversityDepartment of Neurology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityThe Molecular Neuropharmacology Laboratory and the Eye-Brain Research Center, The State Key Laboratory of Ophthalmology, Optometry and Vision Science, Wenzhou Medical UniversityFaculty of Medicine, University of CoimbraThe Molecular Neuropharmacology Laboratory and the Eye-Brain Research Center, The State Key Laboratory of Ophthalmology, Optometry and Vision Science, Wenzhou Medical UniversityDepartment of Neurobiology, Key Laboratory of Molecular Neurobiology, Ministry of Education, Naval Medical UniversityThe Molecular Neuropharmacology Laboratory and the Eye-Brain Research Center, The State Key Laboratory of Ophthalmology, Optometry and Vision Science, Wenzhou Medical UniversityThe Molecular Neuropharmacology Laboratory and the Eye-Brain Research Center, The State Key Laboratory of Ophthalmology, Optometry and Vision Science, Wenzhou Medical UniversityFaculty of Medicine, University of CoimbraDepartment of Neurology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityThe Molecular Neuropharmacology Laboratory and the Eye-Brain Research Center, The State Key Laboratory of Ophthalmology, Optometry and Vision Science, Wenzhou Medical UniversityThe Molecular Neuropharmacology Laboratory and the Eye-Brain Research Center, The State Key Laboratory of Ophthalmology, Optometry and Vision Science, Wenzhou Medical UniversityThe Molecular Neuropharmacology Laboratory and the Eye-Brain Research Center, The State Key Laboratory of Ophthalmology, Optometry and Vision Science, Wenzhou Medical UniversityThe Molecular Neuropharmacology Laboratory and the Eye-Brain Research Center, The State Key Laboratory of Ophthalmology, Optometry and Vision Science, Wenzhou Medical UniversityThe Molecular Neuropharmacology Laboratory and the Eye-Brain Research Center, The State Key Laboratory of Ophthalmology, Optometry and Vision Science, Wenzhou Medical UniversityThe Molecular Neuropharmacology Laboratory and the Eye-Brain Research Center, The State Key Laboratory of Ophthalmology, Optometry and Vision Science, Wenzhou Medical UniversityFaculty of Medicine, University of CoimbraThe Molecular Neuropharmacology Laboratory and the Eye-Brain Research Center, The State Key Laboratory of Ophthalmology, Optometry and Vision Science, Wenzhou Medical UniversityThe Molecular Neuropharmacology Laboratory and the Eye-Brain Research Center, The State Key Laboratory of Ophthalmology, Optometry and Vision Science, Wenzhou Medical UniversityThe mechanism underlying caffeine consumption inversely correlation with depression is unclear. Here, authors identified adenosine A2A receptor in the lateral septum mediating depressive symptoms via direct outputs to the habenula and the hypothalamus.https://doi.org/10.1038/s41467-023-37601-x |
| spellingShingle | Muran Wang Peijun Li Zewen Li Beatriz S. da Silva Wu Zheng Zhenghua Xiang Yan He Tao Xu Cristina Cordeiro Lu Deng Yuwei Dai Mengqian Ye Zhiqing Lin Jianhong Zhou Xuzhao Zhou Fenfen Ye Rodrigo A. Cunha Jiangfan Chen Wei Guo Lateral septum adenosine A2A receptors control stress-induced depressive-like behaviors via signaling to the hypothalamus and habenula Nature Communications |
| title | Lateral septum adenosine A2A receptors control stress-induced depressive-like behaviors via signaling to the hypothalamus and habenula |
| title_full | Lateral septum adenosine A2A receptors control stress-induced depressive-like behaviors via signaling to the hypothalamus and habenula |
| title_fullStr | Lateral septum adenosine A2A receptors control stress-induced depressive-like behaviors via signaling to the hypothalamus and habenula |
| title_full_unstemmed | Lateral septum adenosine A2A receptors control stress-induced depressive-like behaviors via signaling to the hypothalamus and habenula |
| title_short | Lateral septum adenosine A2A receptors control stress-induced depressive-like behaviors via signaling to the hypothalamus and habenula |
| title_sort | lateral septum adenosine a2a receptors control stress induced depressive like behaviors via signaling to the hypothalamus and habenula |
| url | https://doi.org/10.1038/s41467-023-37601-x |
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