Synthesis of Novel Derivatives of 4-Amino-3-(2-Furyl)-5-Mercapto-1,2,4-Triazole as Potential HIV-1 NNRTIs

Synthesis of Novel Derivatives of 4-Amino-3-(2-Furyl)-5-Mercapto-1,2,4-Triazole as Potential HIV-1 NNRTIs

A series of 5-alkylthio (2a-d), 4-arylideneamino (3a-d) and 4-arylideneamino- 5-alkylthio derivatives (4a-f) of 4-amino-3-(2-furyl)-5-mercapto-1,2,4-triazole (1) were synthesized by alkylation of the parent compound with alkyl halides and condensation with aldehydes, respectively. Sulfanyl dimers 5a...

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Bibliographic Details
Main Authors: Erik De Clercq, Myriam Witvrouw, Christophe Pannecouque, Wenfang Xu, Zhong Li, Defeng Wang, Yuan Cao, Xianchao Cheng, Xinyong Liu, Jingde Wu
Format: Article
Language:English
Published: MDPI AG 2007-08-01
Series:Molecules
Subjects:
s-Triazole
Alkylation
Aminomethylation
Synthesis
HIV-1 NNRTIs
Online Access:http://www.mdpi.com/1420-3049/12/8/2003/

Internet

http://www.mdpi.com/1420-3049/12/8/2003/

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