SET SUMOylation promotes its cytoplasmic retention and induces tau pathology and cognitive impairments

SET SUMOylation promotes its cytoplasmic retention and induces tau pathology and cognitive impairments

Abstract PP2A is a major regulator of tau phosphorylation, which is principally regulated by an endogenous nuclear protein inhibitor 2 of PP2A (I2 PP2A), also named SET. However, how SET is post-translationally regulated and translocates from the nucleus to the cytoplasm remain incompletely understo...

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Bibliographic Details
Main Authors: Min Qin, Honglian Li, Jian Bao, Yiyuan Xia, Dan Ke, Qun Wang, Rong Liu, Jian-Zhi Wang, Bin Zhang, Xiji Shu, Xiaochuan Wang
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Acta Neuropathologica Communications
Subjects:
Alzheimer’s disease
SET SUMOylation
PP2A
Tau hyperphosphorylation
Cognitive impairments
Online Access:http://link.springer.com/article/10.1186/s40478-019-0663-0

Internet

http://link.springer.com/article/10.1186/s40478-019-0663-0

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