Ring finger protein 126 promotes breast cancer metastasis and serves as a potential target to improve the therapeutic sensitivity of ATR inhibitors

Ring finger protein 126 promotes breast cancer metastasis and serves as a potential target to improve the therapeutic sensitivity of ATR inhibitors

Abstract Background/aims This study explores the relationship between the E3 ubiquitin ligase Ring finger protein 126 (RNF126) and early breast cancer metastasis and tests the hypothesis that RNF126 determines the efficacy of inhibitors targeting Ataxia telangiectasia mutated and Rad3-related kinase...

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Bibliographic Details
Main Authors: You Pan, Yuchao Yang, Rong Huang, Huawei Yang, Qinghua Huang, Yinan Ji, Jingxing Dai, Kun Qiao, Wei Tang, Longgui Xie, Ming Yin, Jun Ouyang, Shipeng Ning, Danke Su
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Breast Cancer Research
Subjects:
Breast cancer
RNF126
Metastasis
CDK2-mediated
ATR inhibitor
Online Access:https://doi.org/10.1186/s13058-022-01586-0

Internet

https://doi.org/10.1186/s13058-022-01586-0

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