Combining Mass Spectrometry-Based Phosphoproteomics with a Network-Based Approach to Reveal FLT3-Dependent Mechanisms of Chemoresistance

Combining Mass Spectrometry-Based Phosphoproteomics with a Network-Based Approach to Reveal FLT3-Dependent Mechanisms of Chemoresistance

FLT3 mutations are the most frequently identified genetic alterations in acute myeloid leukemia (AML) and are associated with poor clinical outcome, relapse and chemotherapeutic resistance. Elucidating the molecular mechanisms underlying FLT3-dependent pathogenesis and drug resistance is a crucial g...

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Bibliographic Details
Main Authors: Giusj Monia Pugliese, Sara Latini, Giorgia Massacci, Livia Perfetto, Francesca Sacco
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Proteomes
Subjects:
AML
FLT3
drug-resistance
(phospho)proteomic
signaling-network
logic-model
Online Access:https://www.mdpi.com/2227-7382/9/2/19

Internet

https://www.mdpi.com/2227-7382/9/2/19

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