An Igh distal enhancer modulates antigen receptor diversity by determining locus conformation

An Igh distal enhancer modulates antigen receptor diversity by determining locus conformation

Here the authors show enhancers in the Igh locus play a major role in configuring locus architecture and in V(D)J recombination, and identify a link between enhancer hub formation, locus contraction and cohesin-mediated loop extrusion.

Bibliographic Details
Main Authors: Khalid H. Bhat, Saurabh Priyadarshi, Sarah Naiyer, Xinyan Qu, Hammad Farooq, Eden Kleiman, Jeffery Xu, Xue Lei, Jose F. Cantillo, Robert Wuerffel, Nicole Baumgarth, Jie Liang, Ann J. Feeney, Amy L. Kenter
Format: Article
Language:English
Published: Nature Portfolio 2023-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-36414-2

Internet

https://doi.org/10.1038/s41467-023-36414-2

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