A Simple and Sensitive UPLC–UV Method for Simultaneous Determination of Isoniazid, Pyrazinamide, and Rifampicin in Human Plasma and Its Application in Therapeutic Drug Monitoring

A Simple and Sensitive UPLC–UV Method for Simultaneous Determination of Isoniazid, Pyrazinamide, and Rifampicin in Human Plasma and Its Application in Therapeutic Drug Monitoring

As the first-line clinical drugs for tuberculosis (TB), isoniazid (INH), pyrazinamide (PZA), and rifampicin (RMP) are playing important roles for preventing the rapid spread of TB. Precise quantification of these drugs in biological samples is crucial to evaluate or improve the efficacy of advanced...

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Bibliographic Details
Main Authors: Zhimei Jiang, Liang Huang, Lingli Zhang, Qin Yu, Yunzhu Lin, Haotian Fei, Hongxin Shen, Hong Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Molecular Biosciences
Subjects:
isoniazid
pyrazinamide
rifampicin
therapeutic drug monitoring
UPLC–UV
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.873311/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2022.873311/full

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