Inhibition of microtubule detyrosination by parthenolide facilitates functional CNS axon regeneration

Inhibition of microtubule detyrosination by parthenolide facilitates functional CNS axon regeneration

Injured axons in the central nervous system (CNS) usually fail to regenerate, causing permanent disabilities. However, the knockdown of Pten knockout or treatment of neurons with hyper-IL-6 (hIL-6) transforms neurons into a regenerative state, allowing them to regenerate axons in the injured optic n...

Full description

Bibliographic Details
Main Authors: Marco Leibinger, Charlotte Zeitler, Miriam Paulat, Philipp Gobrecht, Alexander Hilla, Anastasia Andreadaki, Rainer Guthoff, Dietmar Fischer
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-10-01
Series:eLife
Subjects:
axon regeneration
spinal cord injury
optic nerve injury
parthenolide
microtuble detyrosination
Online Access:https://elifesciences.org/articles/88279

Internet

https://elifesciences.org/articles/88279

Similar Items