Cellular Metabolism and Bioenergetic Function in Human Fibroblasts and Preadipocytes of Type 2 Familial Partial Lipodystrophy

Cellular Metabolism and Bioenergetic Function in Human Fibroblasts and Preadipocytes of Type 2 Familial Partial Lipodystrophy

LMNA mutation is associated with type-2 familial partial lipodystrophy (<i>FPLD2</i>). The disease causes a disorder characterized by anomalous accumulation of body fat in humans. The dysfunction at the molecular level is triggered by a lamin A/C mutation, impairing the cell metabolism....

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Bibliographic Details
Main Authors: Cristina Algieri, Chiara Bernardini, Fabiana Trombetti, Elisa Schena, Augusta Zannoni, Monica Forni, Salvatore Nesci
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:International Journal of Molecular Sciences
Subjects:
mitochondrial oxidative metabolism
glycolysis
type-2 familial partial lipodystrophy
ATP production
fibroblasts
pre-adipocytes
Online Access:https://www.mdpi.com/1422-0067/23/15/8659

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https://www.mdpi.com/1422-0067/23/15/8659

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