Decreased Vacuolar Ca2+ Storage and Disrupted Vesicle Trafficking Underlie Alpha-Synuclein-Induced Ca2+ Dysregulation in S. cerevisiae

Decreased Vacuolar Ca2+ Storage and Disrupted Vesicle Trafficking Underlie Alpha-Synuclein-Induced Ca2+ Dysregulation in S. cerevisiae

The yeast Saccharomyces cerevisiae is a powerful model to study the molecular mechanisms underlying α-synuclein (α-syn) cytotoxicity. This is due to the high degree of conservation of cellular processes with higher eukaryotes and the fact that yeast does not endogenously express α-synuclein. In this...

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Bibliographic Details
Main Authors: Geert Callewaert, Petra D’hooge, Tien-Yang Ma, Mara Del Vecchio, Vincent Van Eyck, Vanessa Franssens, Joris Winderickx
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Genetics
Subjects:
yeast
Saccharomyces cerevisiae
α-synuclein
Ca2+ signaling
vesicle trafficking
pore formation
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2020.00266/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2020.00266/full

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