The impact of inclusion, dose and duration of pyrazinamide (PZA) on efficacy and safety outcomes in tuberculosis: systematic review and meta-analysis protocol

Abstract Background Pyrazinamide (PZA) is a key component of current and future regimens for tuberculosis (TB). Inclusion of PZA at higher doses and for longer durations may improve efficacy outcomes but must be balanced against the potential for worse safety outcomes. Methods We will search for ran...

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Bibliographic Details
Main Authors: James D. Millard, Elizabeth A. Mackay, Laura J. Bonnett, Geraint R. Davies
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Systematic Reviews
Subjects:
Online Access:https://doi.org/10.1186/s13643-019-1231-1