Facile Synthesis of NH-Free 5-(Hetero)Aryl-Pyrrole-2-Carboxylates by Catalytic C–H Borylation and Suzuki Coupling

Facile Synthesis of NH-Free 5-(Hetero)Aryl-Pyrrole-2-Carboxylates by Catalytic C–H Borylation and Suzuki Coupling

A convenient two-step preparation of NH-free 5-aryl-pyrrole-2-carboxylates is described. The synthetic route consists of catalytic borylation of commercially available pyrrole-2-carboxylate ester followed by Suzuki coupling without going through pyrrole N–H protection and deprotection steps. The res...

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Bibliographic Details
Main Authors: Saba Kanwal, Noor-ul- Ann, Saman Fatima, Abdul-Hamid Emwas, Meshari Alazmi, Xin Gao, Maha Ibrar, Rahman Shah Zaib Saleem, Ghayoor Abbas Chotana
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Molecules
Subjects:
borylation
Suzuki coupling
NH-Free
5-aryl pyrrole-2-carboxylates
iridium-catalyzed
heteroaryl substituted pyrroles
Online Access:https://www.mdpi.com/1420-3049/25/9/2106

Internet

https://www.mdpi.com/1420-3049/25/9/2106

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