Brain-Specific Increase in Leukotriene Signaling Accompanies Chronic Neuroinflammation and Cognitive Impairment in a Model of Gulf War Illness

Brain-Specific Increase in Leukotriene Signaling Accompanies Chronic Neuroinflammation and Cognitive Impairment in a Model of Gulf War Illness

Persistent cognitive impairment is a primary central nervous system-related symptom in veterans afflicted with chronic Gulf War Illness (GWI). Previous studies in a rat model have revealed that cognitive dysfunction in chronic GWI is associated with neuroinflammation, typified by astrocyte hypertrop...

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Bibliographic Details
Main Authors: Sahithi Attaluri, Raghavendra Upadhya, Maheedhar Kodali, Leelavathi N. Madhu, Dinesh Upadhya, Bing Shuai, Ashok K. Shetty
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Immunology
Subjects:
cysteinyl leukotrienes
gulf war illness (GWI)
gulf war-related chemicals
cytokines
5-lipoxygenase
neuroinflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.853000/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.853000/full

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