Global synonymous mutagenesis identifies cis-acting RNA elements that regulate HIV-1 splicing and replication.

Global synonymous mutagenesis identifies cis-acting RNA elements that regulate HIV-1 splicing and replication.

The ~9.5 kilobase HIV-1 genome contains RNA sequences and structures that control many aspects of viral replication, including transcription, splicing, nuclear export, translation, packaging and reverse transcription. Nonetheless, chemical probing and other approaches suggest that the HIV-1 genome m...

Full description

Bibliographic Details
Main Authors: Matthew A Takata, Steven J Soll, Ann Emery, Daniel Blanco-Melo, Ronald Swanstrom, Paul D Bieniasz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC5805364?pdf=render

Internet

http://europepmc.org/articles/PMC5805364?pdf=render

Similar Items