Circulating Exhausted PD-1<sup>+</sup>CD39<sup>+</sup> Helper CD4 T Cells Are Tumor-Antigen-Specific and Predict Response to PD-1/PD-L1 Axis Blockade

Circulating Exhausted PD-1<sup>+</sup>CD39<sup>+</sup> Helper CD4 T Cells Are Tumor-Antigen-Specific and Predict Response to PD-1/PD-L1 Axis Blockade

Tumor-infiltrating exhausted PD-1<sup>hi</sup>CD39<sup>+</sup> tumor-antigen (Ag)-specific CD4 T cells contribute to the response to immune checkpoint blockade (ICB), but their circulating counterparts, which could represent accessible biomarkers, have not been assessed. Here...

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Bibliographic Details
Main Authors: Carlos Martinez-Gomez, Marie Michelas, Clara-Maria Scarlata, Anna Salvioni, Carlos Gomez-Roca, Victor Sarradin, Françoise Lauzéral-Vizcaino, Virginie Féliu, Agnès Dupret-Bories, Gwénaël Ferron, Jérôme Sarini, Christel Devaud, Jean-Pierre Delord, Camille-Charlotte Balança, Alejandra Martinez, Maha Ayyoub
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Cancers
Subjects:
CD4 T-cell response
tumor antigens
cancer immunotherapy
circulating biomarkers
Online Access:https://www.mdpi.com/2072-6694/14/15/3679

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https://www.mdpi.com/2072-6694/14/15/3679

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