A framework for Frizzled-G protein coupling and implications to the PCP signaling pathways

A framework for Frizzled-G protein coupling and implications to the PCP signaling pathways

Abstract The ten Frizzled receptors (FZDs) are essential in Wnt signaling and play important roles in embryonic development and tumorigenesis. Among these, FZD6 is closely associated with lens development. Understanding FZD activation mechanism is key to unlock these emerging targets. Here we presen...

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Bibliographic Details
Main Authors: Zhibin Zhang, Xi Lin, Ling Wei, Yiran Wu, Lu Xu, Lijie Wu, Xiaohu Wei, Suwen Zhao, Xiangjia Zhu, Fei Xu
Format: Article
Language:English
Published: Nature Publishing Group 2024-01-01
Series:Cell Discovery
Online Access:https://doi.org/10.1038/s41421-023-00627-y

Internet

https://doi.org/10.1038/s41421-023-00627-y

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