Buprenorphine in rats: potent analgesic or trigger for fatal side effects?

Buprenorphine in rats: potent analgesic or trigger for fatal side effects?

Abstract With ongoing animal welfare efforts, multimodal analgesia is often recommended to implement in study protocols. Buprenorphine with very potent analgesic effect is a standard opioid for the use in this context in rats. In this study, two rat strains (LEW/NHanZtm, n = 6 and Crl:CD(SD), n = 8)...

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Bibliographic Details
Main Authors: Janin Reifenrath, Miriam Heider, Merle Kempfert, Heidi Harting, Friederike Weidemann, Sarah Strauss, Nina Angrisani
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Acta Veterinaria Scandinavica
Subjects:
Adverse effect
Lewis
Opioid
Pain management
Refinement
Rodent
Online Access:https://doi.org/10.1186/s13028-022-00661-y

Internet

https://doi.org/10.1186/s13028-022-00661-y

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