Buprenorphine in rats: potent analgesic or trigger for fatal side effects?
Abstract With ongoing animal welfare efforts, multimodal analgesia is often recommended to implement in study protocols. Buprenorphine with very potent analgesic effect is a standard opioid for the use in this context in rats. In this study, two rat strains (LEW/NHanZtm, n = 6 and Crl:CD(SD), n = 8)...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-12-01
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| Series: | Acta Veterinaria Scandinavica |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13028-022-00661-y |
| _version_ | 1811291405215072256 |
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| author | Janin Reifenrath Miriam Heider Merle Kempfert Heidi Harting Friederike Weidemann Sarah Strauss Nina Angrisani |
| author_facet | Janin Reifenrath Miriam Heider Merle Kempfert Heidi Harting Friederike Weidemann Sarah Strauss Nina Angrisani |
| author_sort | Janin Reifenrath |
| collection | DOAJ |
| description | Abstract With ongoing animal welfare efforts, multimodal analgesia is often recommended to implement in study protocols. Buprenorphine with very potent analgesic effect is a standard opioid for the use in this context in rats. In this study, two rat strains (LEW/NHanZtm, n = 6 and Crl:CD(SD), n = 8) underwent orthopaedic surgery and received carprofen, buprenorphine and a local anaesthetic in a multimodal setup. Crl:CD(SD) rats showed severe side effects in the first 24 h after anaesthesia, predominantly manifesting in pica-behaviour and reaching humane endpoints in two of eight animals, while LEW/NHanZtm rats showed only slight depression in the first postoperative days. In the context of improving animal welfare in experimental studies, buprenorphine is highly recommended not to be used in male Crl:CD(SD) rats and should generally be used very carefully and only if required. |
| first_indexed | 2024-04-13T04:28:54Z |
| format | Article |
| id | doaj.art-ba13e35c356f477dac933e01ba457079 |
| institution | Directory Open Access Journal |
| issn | 1751-0147 |
| language | English |
| last_indexed | 2024-04-13T04:28:54Z |
| publishDate | 2022-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Acta Veterinaria Scandinavica |
| spelling | doaj.art-ba13e35c356f477dac933e01ba4570792022-12-22T03:02:23ZengBMCActa Veterinaria Scandinavica1751-01472022-12-016411510.1186/s13028-022-00661-yBuprenorphine in rats: potent analgesic or trigger for fatal side effects?Janin Reifenrath0Miriam Heider1Merle Kempfert2Heidi Harting3Friederike Weidemann4Sarah Strauss5Nina Angrisani6Hannover Medical School, Clinic for Orthopaedic SurgeryHannover Medical School, Institute for Laboratory Animal Science and Central Animal FacilityHannover Medical School, Clinic for Orthopaedic SurgeryHannover Medical School, Clinic for Orthopaedic SurgeryHannover Medical School, Trauma DepartmentHannover Medical School, Department of Plastic, Aesthetic, Hand and Reconstructive SurgeryHannover Medical School, Clinic for Orthopaedic SurgeryAbstract With ongoing animal welfare efforts, multimodal analgesia is often recommended to implement in study protocols. Buprenorphine with very potent analgesic effect is a standard opioid for the use in this context in rats. In this study, two rat strains (LEW/NHanZtm, n = 6 and Crl:CD(SD), n = 8) underwent orthopaedic surgery and received carprofen, buprenorphine and a local anaesthetic in a multimodal setup. Crl:CD(SD) rats showed severe side effects in the first 24 h after anaesthesia, predominantly manifesting in pica-behaviour and reaching humane endpoints in two of eight animals, while LEW/NHanZtm rats showed only slight depression in the first postoperative days. In the context of improving animal welfare in experimental studies, buprenorphine is highly recommended not to be used in male Crl:CD(SD) rats and should generally be used very carefully and only if required.https://doi.org/10.1186/s13028-022-00661-yAdverse effectLewisOpioidPain managementRefinementRodent |
| spellingShingle | Janin Reifenrath Miriam Heider Merle Kempfert Heidi Harting Friederike Weidemann Sarah Strauss Nina Angrisani Buprenorphine in rats: potent analgesic or trigger for fatal side effects? Acta Veterinaria Scandinavica Adverse effect Lewis Opioid Pain management Refinement Rodent |
| title | Buprenorphine in rats: potent analgesic or trigger for fatal side effects? |
| title_full | Buprenorphine in rats: potent analgesic or trigger for fatal side effects? |
| title_fullStr | Buprenorphine in rats: potent analgesic or trigger for fatal side effects? |
| title_full_unstemmed | Buprenorphine in rats: potent analgesic or trigger for fatal side effects? |
| title_short | Buprenorphine in rats: potent analgesic or trigger for fatal side effects? |
| title_sort | buprenorphine in rats potent analgesic or trigger for fatal side effects |
| topic | Adverse effect Lewis Opioid Pain management Refinement Rodent |
| url | https://doi.org/10.1186/s13028-022-00661-y |
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